The 2013 ION Symposium on Frontier of Neuroscience was held at the SIBS Lecture Hall on May 11th, 2013. Prof. Liqun Luo (Stanford University), Prof. Naoshige Uchida(Harvard University), Prof. Marla Feller ( University of California, Berkeley), Prof. Li-Huei Tsai (Massachusetts Institute of Technology), Prof. Scott Sternson (Janilia Farm Research Campus) and Prof. Robert Malenka (Stanford University) , all pioneers in neuroscience, presented exciting talks in the symposium. More than 200 researchers attended the symposium and some attended student lunches with the speakers.